It's about friendship between two friends and how their life changes when a new girl comes into their life and how their friendship will be impacted upon her arrival where a tiny misunderstanding leads to a war between two close friends.

Chandra Shekar "Chandram" loves and marries Gowri. Soon, Chandram gets a job in an estate owned by Surendra Nath a decadent person who behaves like a gentleman and provides good hospitality. Later, once Gowri is alone, tries to molest her but Chandram arrives in time, and the quarrel ensues into the death of Surendra Nath. Chandram is sentenced to death but, on the way to prison, the police van meets with an accident and all occupants are dead.

Pilla Nuvvu Leni Jeevitham is the kind of film which borrows a little bit of everything from the magic recipe of a commercial entertainer, although it doesn't quite leave a mark of its own in the end.